Missing Markers | Sage Insights

Sage's Healthcare Philosophy

Today's healthcare system relies on outdated testing protocols that focus on basic biomarkers while overlooking the most scientifically validated predictors of future health problems. Sage helps you identify these critical testing gaps, understand their significance for your personal health profile, and take proactive measures before serious conditions develop.

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Sage Insights

Cardiovascular Health Markers

Hormone Health Markers

Metabolic Health Markers

Inflammation Markers

Sage Insights:

AI-Powered Biomarker Gap Analysis

Our advanced artificial intelligence doesn't just analyze your existing lab tests—it identifies critical biomarkers missing from your health assessment. Sage Insights automatically detects which essential health markers you should be tracking based on your age, biological sex, existing test results, and personalized health goals.

Personalized advanced testing recommendations based on your comprehensive health profile

AI-powered analysis of complex relationships between interrelated biomarkers

Evidence-based explanations of why specific advanced tests matter for YOUR individual health

Actionable recommendations for discussing advanced testing with your healthcare provider

Integration of cutting-edge medical research on the most predictive biomarkers for disease prevention

Cardiovascular Health Markers

Advanced Cardiovascular Risk Assessment:

Beyond Basic Cholesterol Testing

Standard lipid panels only measure total cholesterol, HDL, and LDL—but advanced blood panel analysis reveals much more. These deeper insights can uncover hidden cardiovascular risks long before they become clinical problems.

Our blood test results analysis identifies key patterns often missed in routine lab test results, helping you take preventive action now—not after symptoms appear.

Missing Marker 1:

Apolipoprotein B (ApoB)

ApoB is the protein component of LDL and other atherogenic particles that actually penetrate arterial walls—providing a direct measure of the particles that cause atherosclerosis and cardiovascular disease

Scientifically validated as more predictive of cardiovascular risk than standard LDL measurements
Can be significantly elevated even when LDL cholesterol appears within "normal" ranges
Identifies individuals with small, dense LDL particles (associated with higher cardiovascular risk)
Recognized by cardiovascular specialists as superior to conventional lipid markers for risk assessment

Two patients can have identical LDL cholesterol numbers but vastly different ApoB levels—indicating dramatically different actual cardiovascular risks. Without measuring ApoB, you're missing a critical dimension of your complete cardiovascular health assessment.

Sage Insights AI thoroughly analyzes your existing lipid panel results and determines if your specific biomarker patterns warrant ApoB testing. It examines relationships in your current markers that suggest potential ApoB elevation and provides clear, evidence-based recommendations for discussion with your healthcare provider.

Missing Marker 2:

Lipoprotein(a) or Lp(a)

Lp(a) is a genetic variant of LDL cholesterol that promotes arterial inflammation and blood clotting. Often described as "the most dangerous cholesterol biomarker you've never heard of" in cardiovascular medicine.

Inherited genetic risk factor for early heart attack, stroke, and cardiovascular disease
Not significantly influenced by diet or standard exercise interventions (unlike other lipid markers)
Affects approximately 20% of the population with elevated levels
Requires specific targeted treatment approaches different from standard cholesterol management

Lp(a) is rarely included in standard cardiovascular assessment, even though elevated levels can triple heart attack risk. Since levels are genetically determined, discovering high Lp(a) allows family members to get tested and implement appropriate preventive strategies.

Our advanced AI examines your cardiovascular history, existing lipid biomarker results, and personal cardiovascular risk factors to determine if Lp(a) testing would provide valuable information for your health profile. If you've already been tested, Sage Insights provides clear context about what your specific Lp(a) results mean and appropriate personalized next steps.

Hormone Health Markers

Comprehensive Hormone Assessment:

Beyond Basic Thyroid and Sex Hormone Testing

Standard hormone testing typically checks just one or two basic markers, missing the complex interplay between various hormonal systems. Comprehensive hormone testing provides a more complete picture of endocrine health and hormonal balance.

Missing Marker 1:

Complete Thyroid Function Panel

Beyond basic TSH testing, a complete thyroid function assessment includes Free T3, Free T4, Reverse T3, and thyroid antibody testing for thorough evaluation.

Many individuals have "normal" TSH results but abnormal T3 or T4 levels affecting metabolism
Thyroid antibody testing can identify autoimmune thyroid conditions before TSH levels change
Reverse T3 testing can reveal stress-induced thyroid hormone resistance
T3:T4 ratio analysis provides insight into thyroid hormone conversion efficiency

A basic TSH test alone fails to detect early thyroid dysfunction and the root causes of thyroid-related symptoms. Many people suffer with unexplained fatigue, weight management issues, and cognitive problems for years because their complete thyroid function isn't properly assessed.

Our AI analyzes your reported symptoms alongside any existing thyroid biomarker results to identify patterns suggesting the need for comprehensive thyroid assessment. It provides clear visualizations of thyroid hormone relationships and personalized recommendations for achieving optimal thyroid function based on your unique profile.

Missing Marker 2:

Comprehensive Sex Hormone Panel

Beyond basic estradiol or testosterone measurement, includes complete assessment of estrone, estriol, progesterone, DHEA-S, and their metabolites for complete hormonal evaluation.

Hormone ratios and balance often matter more than absolute hormone levels
Hormone metabolite testing reveals how your body processes key hormones
Provides detailed insight into perimenopause/andropause transitions and hormonal shifts
Helps identify root hormonal causes of specific symptoms for targeted treatment

Basic hormone testing frequently leaves women experiencing perimenopause or men with age-related hormonal changes without clear answers. Comprehensive hormone assessment reveals the subtle hormonal shifts driving symptoms and long-term health risks.

Our sophisticated AI correlates your age, reported symptoms, and any existing hormone test results to identify which additional hormone biomarkers would provide the most valuable information for your specific situation. It also analyzes complex hormone relationships and provides evidence-based insights about optimizing your hormonal health and balance.

Metabolic Health Markers

Advanced Metabolic Health Assessment:

Detecting Insulin Resistance Years Earlier

Conventional testing often identifies metabolic problems only after they've progressed to prediabetes or clinical insulin resistance. Earlier detection through advanced metabolic biomarkers enables more effective prevention strategies.

Missing Marker 1:

Fasting Insulin Measurement

A direct measure of insulin levels after fasting, revealing how intensively your pancreas must work to maintain normal glucose levels and metabolic function.

Fasting insulin rises years before blood glucose becomes abnormal
Directly linked to metabolic syndrome development and type 2 diabetes risk
Strong predictor of future weight management challenges and metabolic efficiency
Associated with systemic inflammation and increased cardiovascular risk

Fasting glucose or HbA1c testing alone fail to detect the earliest signs of metabolic dysfunction. Many individuals have "normal" glucose readings but significantly elevated insulin levels, indicating metabolic problems years before standard testing would identify them.

Our AI examines your glucose history, lipid patterns, trends, and related markers to identify early signs of insulin resistance. It provides personalized recommendations for metabolic optimization based on your unique pattern of biomarker results and health history.

Missing Marker 2:

HOMA-IR (Homeostatic Model Assessment of Insulin Resistance)

Homeostatic Model Assessment of Insulin Resistance—a calculated value using glucose and insulin measurements that precisely quantifies insulin resistance and metabolic function.

Quantifies insulin resistance before glucose abnormalities develop
Helps distinguish between different types of metabolic dysfunction
Provides an objective baseline to measure intervention effectiveness
Strongly linked to future cardiometabolic disease risk

Without directly measuring insulin resistance, healthcare providers often dismiss early metabolic warning signs. HOMA-IR calculation reveals metabolic problems while they're still reversible through targeted lifestyle interventions.

When you have both glucose and insulin test results available, our AI automatically calculates your HOMA-IR value and tracks it longitudinally over time. It analyzes trends in this critical metabolic marker and provides actionable steps for improving insulin sensitivity based on evidence-based interventions.

Inflammation Markers

Inflammatory Biomarkers:

The Silent Drivers of Chronic Disease Development

Chronic inflammation underlies many health conditions, yet standard testing rarely measures these critical inflammatory biomarkers. Comprehensive inflammation monitoring helps identify root causes of symptoms and disease risk before clinical manifestation.

Missing Marker:

High-Sensitivity C-Reactive Protein (hs-CRP)

A sensitive marker of systemic inflammation that indicates increased cardiovascular risk and inflammatory burden.

Independent predictor of heart attack, stroke, and cardiovascular event risk
Helps identify hidden inflammatory processes before symptoms develop
Guides intensity of preventive health strategies based on risk level
Monitors effectiveness of anti-inflammatory lifestyle interventions

Standard medical assessment often ignores inflammatory status until disease manifests clinically. Tracking hs-CRP reveals whether your lifestyle modifications are actually reducing your inflammatory burden and disease risk.

Our AI correlates your hs-CRP results with other inflammatory biomarkers and health conditions to provide context about your specific inflammatory status. It identifies patterns suggesting specific causes of inflammation and tracks the effectiveness of your anti-inflammatory interventions longitudinally.

Nutritional Markers

Critical Nutrient Status Assessment:

Beyond Basic Vitamin Testing

Standard blood work rarely includes comprehensive nutritional biomarker testing, despite deficiencies playing major roles in energy production, immune function, and chronic disease risk.

Missing Marker 1:

Vitamin D (25-Hydroxyvitamin D)

The active circulating form of Vitamin D that accurately indicates your body's true vitamin D status and sufficiency.

Essential for immune regulation, bone metabolism, and mood stabilization
Deficiency linked to numerous chronic diseases and health conditions
Optimal levels differ significantly from conventional "normal" reference ranges
Difficult to achieve optimal levels without testing and personalized supplementation

Vitamin D is tested inconsistently and often evaluated using outdated reference ranges. Optimal levels for disease prevention are typically higher than standard "normal" laboratory ranges suggest.

Our AI tracks your Vitamin D levels longitudinally and in relation to seasonal variations. It provides personalized recommendations for reaching and maintaining optimal vitamin D levels based on your specific test results, geographical latitude, age, and other relevant factors.

Missing Marker 2:

Omega-3 Index Testing

Measures the percentage of EPA and DHA (essential omega-3 fatty acids) incorporated in red blood cell membranes, reflecting tissue levels.

Directly linked to cardiovascular health outcomes and disease risk
Associated with cognitive function, neurological health, and brain aging
More accurate than dietary questionnaires for assessing true omega-3 status
Helps determine personalized optimal supplementation strategies

Despite strong scientific evidence linking omega-3 status to health outcomes, this test is rarely included in standard medical assessments. Many people supplementing with fish oil have no objective way to know if they're reaching therapeutic tissue levels.

For those who have completed omega-3 index testing, our AI provides context for your specific results and tracks changes in response to dietary modifications or supplementation protocols. It also analyzes your personal risk factors to determine if this specialized testing would be particularly valuable in your comprehensive health monitoring.

Comprehensive Biomarker Assessment:

Don't Wait Until Problems Develop

Whether you want to analyze your blood work, explore blood work analysis, or get your lab results explained in plain language, Sage gives you the clarity to act early. Our AI-driven system connects the dots across your health test results, providing the insights you need to stay ahead of potential risks.

Take control of your long-term health today with intelligent lab results interpretation and personalized blood test interpretation powered by Sage.