TSH (thyroid-stimulating hormone) is the primary screening test for thyroid health, measuring the signal from the pituitary gland that tells the thyroid how much hormone to produce. High TSH may indicate an underactive thyroid, while low TSH may suggest an overactive thyroid. Because TSH is only a screening marker, it's best interpreted alongside tests like Free T4 and monitored over time, as thyroid function can change with factors such as stress, illness, medication, pregnancy, and age. Consistent testing provides a more accurate picture than a single result.